I have never heard the m22's so I can't really comment. However, I really do love my m80's.
From what I've read if you really like the detail of your m22's then you should either a.) stick with m22's or b.) upgrade to m80's. They say the m60's have a more laid back sound so you may not like the switch if you've grown to love the m22's.
since you are running a sub tho you might not notice a huge difference... how big is your room?
the room is 17x22, but I've been hearing/reading a lot that the m22 and sub is close to the m80's and I'm not missing much.