With that setup, you are kinda trying to make a home theater out of half a room. It's tough doing that.
In my opinion, moving the TV in front of the window would be a much better option. That way, you can spread out the m22's, get a nice open viewing area instead of a closed off one. You could put one of the QS4's/QS8's above the fireplace, the other one on the other wall.
I'm assuming there is a wall off to the right in the picture. If there is, I think this way would work out perfectly. That is the way most home theaters work out the best, in a long rectangle-ish room.
Having that TV in that little niche is really hard to set up a good audio set up. It's kinda screaming to be moved to an "open" spot.
Good luck! More pictures of your room might help.
