I don’t suppose you could turn the room layout around so that the door is to your back could you? If not, I’d still go for some towers. You’ve got a nice sized room and I don’t think the 22’s will be enough for you. I’d build a stage that is either angled or with a radius. By doing this, the egress traffic will naturally walk to avoid tripping over it. I think you will be OK. Pencil it out and try to keep a 36” path from the door into the room.