I have 22s and a 150 up front, 8's in the back, and a 350 providing the thump. My room is smaller (but taller) than yours and my system will fill it to the brim. BUT... personally I feel my room may at the edge of capability for the M22ti as I like high-dB sessions. That being said, for mortal listening the 22 is quite a speaker.

"That's some catch, that Catch-22." "It's the best there is." M22ti VP150 EP350 QS8 M3Ti