There is definately something to be said about having matching LCR speakers. I would have the space under the screen to use M22 across. That way the tweeter level would all be the same, but below the screen across the stage.

The M60 and M80 have the 6.5" woofers, if when I listen to sound tracks on the movies will I miss any mid-bass compared to the M22?

From reading, the weakest link would be the VP150 as it compromises for placement ease?

How about M22 as LCR with a EP600 horitizontally positioned at the stage lip?