Keith, it would be my guess that the 60's or 80's would be a better fit to fill that 6,480 cu ft room. I have owned both 60v2's and 80v2's and my room is larger than yours.
The 80's will give you a little more in the detail area because of the dual tweeters and dual midrange drivers. Plus they can handle a lot more power. I've never owned the 22's, but I'm guessing even the 60's would perform better in the detail category and achieve louder levels as well.
Maybe someone else will chime in that has upgraded from 22's to 60's or 80's.
