BC, you do seem to be interested in doing things the hard way instead of simply using the 4306 with the bass management that it would provide, but be that as it may, sure, you can hook up to the high level inputs on the EP500. You can run speaker wires directly from the outputs of the Anthem to the EP500; there's no need to have the M80s involved in the chain.

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Enjoy the music, not the equipment.