I had the opportunity to a/b the M22+EP350 vs the M60 and the M80.
Comparing the M22+sub to the M60 I was not sure which I liked more. They were different, but not as different as I would have expected. The vocals on the M22 are slightly more forward, and the sub gives more bass. The bass opened up with the M22/sub combo. I would have to agree with Jake that the M60 is a little fuller.
I would not consider anything less than the EP350 with the M22. The 175 is very weak. At almost full volume in a 12x20x8 room it barely had any rumble on some very rumbley ROTR scenes.