With my 3808 I used audyssey to calibrate my speakers at first. I thought the results were ok, but ended up having issues with the receiver reverting to it's original auddysey settings (I had made a few adjustments here and there.)
In the end, I just reset my receiver and set up everything by hand.
I may go back and re-run it sometime and experiment with the room EQ.
I say try out the audyssey setup first for sure. You can always hit the "EQ" button on the remote to to turn off the EQ if you are not satisfied with the results.
