Well, that's a big room with an open-floor plan. Depending on your listening habit, the room deserves a flagship sub from Hsu or SVS...

Cylinders: Hsu TN-1220HO or SVS CS-Plus series
Boxes: Hsu VTF-3 or SVS PB2-Plus

Box vs. cylinder is, to a large extent, a matter of ergonimic and aesthetic preferences. Either way, I warn you that these subs are very large (except for the VTF-3, the most compact of these, although it is still physically substantial).