I'd say in that room, you'll want towers; probably M60s. If you can swing it, do the M60s and a VP100 or 150 now, then get the surrounds later.

Are you planning to listen to music on this setup? I mean, you'll end up doing it anyway, but if that's no focus on that, you could do M50s for your fronts to save a little dough. I think I'd prefer the M60s for music in general (although the M50s are no slouches), simply for the sake of imaging. Now, I haven't heard M50v2s, so they may have improved along those lines over my M50tis.

I am the Doctor, and THIS... is my SPOON!