I would concur with the others, if you have the space, definitely go with the M60's. I originally had the M22's in a L/R configuration and as good as they sound I found that when it came to a home theater OR musical application where you are listening at reasonably high volume levels along with the dynamics to go with them, the M22's strained a little bit at the medium low end. That is where a full range speaker like the M60 shines because it can handle that without any problem. In that respect, at least in my opinion and being able to compare the two set-ups, I have found full range speakers like the M60 actually integrate better with subs than a bookshelf speaker like the M22.
