It's certainly possible. It may not be optimal, but that's how some of us have to live. The M3s are quite good speakers; I think I may prefer the M22s. But I haven't heard them back to back, and I haven't heard them in the same environment.

The M22s actually appear much smaller in person (although I have M80s, so my perceptions may be a tad skewed.) The narrow grills help with this.

I am the Doctor, and THIS... is my SPOON!