yes, you can split the signal at the receiver or at the subs, but it still is just one signal with my current receiver. Running seperate lines would help setup me up for if I ever get a receiver with seperate lfe-out jacks for seperate calibration of each sub. The newer versions of Audyssey will actually do an independent calibration of each sub, but that is only if the receiver is setup for that.
I guess I'm just looking for best practices for wiring a room for multiple sub locations.