I was just told by someone (still asking for documented research to verify it) that if using an AT screen that you should remove the speaker grills. Something about it being a measurable difference in sound.
Seems plausible. Consider the following. How many layers of acoustically transparent material could you add in front of a speaker before it made an audible difference. Maybe not two, but three? Four? When you start adding layers, you'll approach the realm of audibility.
Seems like prudent advice.