I'd recommend seven active LFR each for the first layer, seven active M5 on-walls for the second layer and an active M5 on-ceiling for VoG for the third layer.

As for subs, a single 800 for the .1 and VoG and seven 500s for the first and second layers. Each 500 would be connected to the 14.1-channel DSP serving each LFR and M5.

101 channels of ADAs would suffice.

I'll make you a deal, Phil. If you pay for it all, I'll install it at my place and give you a full report.

House of the Rising Sone
Out in the mid or far field
Dedicated mid-woofers are over-rated