Set all speakers to small, with a receiver crossover of 80hz. Turn the crossover knob on the 350 all the way clockwise to the highest setting to get it out of the way for receiver management. This setting is the norm for most people, and also THX recomendation. If your receiver will allow for different crossovers for each speaker, the crossover setting may differ from speaker to speaker. The only speaker you MIGHT try large on, would be the 80's with LFE+Main on the receiver. However, I would still use small. A lot depends on your room size also.
M80s-VP180-QS8s-EP600-2xEP350 Denon3808 Outlaw7700