I went from M22's to M60's and heard a considerable difference in the fullness of the sound. It was an immediate smile and just the sound I was looking for that the 22's didn't provide. I put the 22's to work as surrounds and I love the setup. It is very impressive in both movies and multi channel discs. (Just did a test with the Star Wars episode I pod race scene at 105db, and it was insane. I am very pleased with the setup).

The VP 100 is a great speaker and will sound fine with that setup but if you are like most of us you will also wonder if the 150 would sound better. I upgraded from the 100 to the 150 as my curiousity got the best of me. (Just wanted to have the best one that Axiom offered, besides the fact that the 150 gets more comments as being a cool looking speaker than any of the others due to its size compared with most center channels that people get)
And the 150 was an asthetically more pleasing speaker for me as it is the same width as my TV. Cool!