I would go with M60s (or 22s, 2s, whatever) for a pure 5.1 music system but QS8s for a dual-use or HT system. The QS8s are very good at making your room seem much larger than it really is, which is a real plus for HT.

M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8