My family room which is for movies as well as stereo listening is 2400cu/ft and i couldn't imagine using M2's in that size of a room.
However, i have a speaker similar to the M2's (same size of drivers, but different brand) in my bedroom with an 8" sub. My bedroom is about 800cu/ft, and in that room of that size of those speaker sounds wonderful...
If i was in your situation, personally i would go with a setup similar to JohnK's.. M22's with a pair of EP500's, or a horizontal ep600/800... Put the M22's on stands, and then go from there..
Is there a budget in mind? If there is somewhat of a budget in mind the 600/800 idea may not be feasible.