I made the upgrade from M22's to M60's due to my room size even though I was running a sufficient sub with the 22's. I was delighted when I got the 60's. It took no time for me to say, "YES! This is what I was looking for", when I plugged the 60's in for the first time.

With your size room you would stand to benefit from the increased low-end performance of tower speakers over bookshelf.