Small speakers have some interesting things going for them. Because the woofer and tweeter are so close together, and because the box is so small, they image like champions. Instruments will be precisely located in space. That can be quite wonderful.
The downside to a physically small enclosure is lack of bass output and a limit to the volume of sound that can be produced. That being said, the MZero's with a subwoofer in a small room will be quite an entertaining system. As an example, I have an old set of RadioShack Minimus 7s. Every now and then I replace my main speakers with them and run them with my sub. No one can believe that the sound that they are hearing comes from those two tiny boxes.
