I agree with you Chess wholeheartedly.
But...but... Why would you say a sub bass would overpower/muddle the mid and highs? On the contrary on my personal experience the sub still blended well with the mini monitor. I still heard the detail and depth clearly present in the mini-monitor and the sub covered the rest of the lower frequecy. This is based on some 8 inch and some 6.5 inch driver subwoofers. Yes they are relatively small but the bass was seemless. When playing music I didn't even equate the sound coming from the sub area. The bass was all around.

With a floorstander some of the mid frequency is shared by the woofers. By offloading the lower frequencies 80hz and lower to the sub the woofers would concentrate on a shorter range of frequencies. So upper bass and lower mid range frequencies are more distinct(don't quote me on that).
Wouldn't the same principle apply to mini monitors? But doesn't having a smaller box decreases the chance of colouration?