I know a couple of people who bought M22s for no-sub music systems and ended up having to add a sub before they were really happy with them. Everyone I know with M3-only systems is perfectly happy with them and doesn't feel the need for a sub.

Definitely go with M3s.

M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8