For a stereo music system I would DEFINITELY go with 50s or 60s over M22s and sub, unless the room was quite small. As an M60 owner I will obviously suggest you try for the 60s

M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8