Moorthy, I also would say to go with a floorstanding design. Even with a sub, the 50's, 60's or 80's will give you a better blend of bass throughout that large of a room. My room is 31ft x 30ft and my 60's work nicely. I would not want the smaller 22's for that big of a room. When I had a 350, it did ok for my room, however, since I've upgraded to a Factory Outlet 500, it is like night and day.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85