For that big of a room, I would consider M22s on the ledges at either end of the lower unit with a VP150 under the tv.
M60's at the ends of the unit with a VP150 center would be even better
The sub can go in a corner somewhere in the room, or under an end table, etc.
You need 14 inches for M3s to go on one of the upper shelves, but they should work, specially if you can place them forward on the shelf.
Order some custom samples to see if you can match the cabinet.
OT: I was at Loyola from 72-76 and have been in that area. Sorry about your loss and hope you are recovering well. You said you, the dog and truck got out. I take it the spouse came along in the last year.
