That sub and M22's should give great results. During my search for speakers, a lot of people said that the VP100 and VP150 sound very close to the same, just that the VP150 will play louder without distortion (mainly for use in large rooms). I'm using the VP100 with M22's and I'm completely satisfied. Haven't heard the VP150, but its a fair bump in price when it supposedly sounds the same.
Another considerstion is a vertical M22 for the center. This should give a seamless blend across the front since all three speakers would be the same. It depends on whether you have the room for this or not, but it would be your best bet in terms of sound quality. To sound their best, the tweeters on center/mains should be at the same height, so space constraints may make this option impossible.
