Yes, I would say a Musical Fidelity amp is overkill for the Axioms, at least in a small room where you don't need much power. Also, if you use your computer as a sound source, it will probably be the weakest link in your system, by far. That is, unless you have a super-good sound card.
I understand that the M22's are more neutral than the M3's. I own the M22's, and I can definitely attest to their accuracy. I highly recommend them. If you listen to a lot of CDs, I would also recommend a dedicated CD player: Cambridge Audio, Denon, or Yamaha are just a few good ones.
It is technically possible to connect a sound card straight to an amp, using the Windows volume control, but it might not provide enough gain. You should have a preamp anyway. I got a Harman Kardon HK 3470 stereo receiver because it has preamp-out / main-in jacks. This means that it can be plugged into a surround receiver as a dedicated amp, in the future.
-Cooper
