I like the Harmony that I have (670? something like). The Harmony buttons tend to be poorly laid out, especially on the early 600 series and the 800 series. They've got the shape right, but they're pretty dumb about the important buttons. The TiVo remotes are still the most intelligently designed remotes I've ever seen, but they're not really multifunction.
There's a few things I would like to do with the Harmony that I haven't been able to, but that's mostly because Yamaha won't give me their IR codes.
I don't see much sense in the big touchscreen remotes like the 1000 or the Pronto--if you can't feel it in the dark (or feel where the important buttons are at all), it's just hard to use.
