I've had a Harmony 880 for the past couple years. The programming interface has become excellent. It is leaps and bounds ahead of what it was a year or two ago. You can setup the multiple receivers and have the volume only adjust the volume on one receiver across all of your "Activities" or break it down if you'd like.

I don't think I would buy a different brand of remote because I've had such good luck with my Harmony.

HG Cherry M80's, QS8's, VP150, and a pair of EP500's