My setup is identical to yours except I have the M60s instead of the M22s. I've got my fronts set to LARGE and the sub set to 60Hz, which forces the M60s to be set at the same point with the H/K 525. I believe the settings are in 20Hz increments, I've got the VP150 at 80Hz and the QS8s at 100Hz.
You may want to play with setting the fronts to SMALL and using overlapping frequencies for the sub and the M22s and see what sounds best. Play around, every room affects the output drastically, so try my suggestion and others that will surely follow and get a 'feel' for your room. Have fun, you've got a great system.
