Fred, room effects(e.g. see Mark Johnson or Randy)far exceed the fluctuations in response that well-designed speakers exhibit. You try to start off with the flattest anechoic response possible, since fluctuations can possibly coincide with room effects and make the net result worse. "Ruler flat" response is typical of even modest-cost players and receivers, but doesn't exist in speakers, regardless of price.

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Enjoy the music, not the equipment.