I would mention that the sound difference might be shocking to you going from the laid back M50 to the ultra precise M22, maybe the M3 might be more to your tastes, not to disuede you from the M22s.

Yes the M22 VP150 work perfectly together, better than the M3s do, IMO. And the M3s are said to sound very similar to the M50s.

So far as v1 to v2 I have mixed and matched my v1 M22/VP100/3 QS8s with the v2 M80s and VP150 with out any problems.

Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70