The only thing I'm unsure about is the delay (distance) setting for each sub. Since most receivers only have ONE preout for the sub, you would most likely have to average the distances of the 2, 3, or 4 subs. That is what I do now for my 3 subs.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85