I figure someone here has used a couple of M22s instead of a single VP150 (a little more $ but not much). I wonder if someone were to use such a setup, would it be better to use the 22s horizontally with the tweeters in the central position...flank position(tweeters out)...or better to stand them upright side/side tweeters up?

Half of communication is listening. You can't listen with your mouth.