I wouldn't suggest it since musical instrument speakers are generally much heavier duty with bigger speaker magnets and larger voice coils to be able to take the pounding. They are also designed to operate in a much more limited frequency range. That is why you still see a lot of 12" and 15" size speakers in musical instrument cabinets and PA's but you don't see them that often anymore in A/V speakers. Not that many years ago I tried an electric guitar(not even a bass) thru my A/V speakers in which nowadays the largest are usually 8" in diameter and it didn't require much volume before they started to distort.
