Have you considered using headphones. They would be fantastic in a small room for music but speakers would be a little better for movies and games.
That said the M22s are a fantastic choice especially since you can demo them for 30 days. You might consider an M2 center to go with the M22s if you can fit one above or below your screen. I think Fred is using 2 of them as centers for his M80s.
If you plan on this system staying in this room I would go with the QS4, however if you think there’s a chance you might be moving it to a larger room I would consider the QS8s. Also I would stick with 5.1 for now.