Unless you believe you have a golden ear, then no, you shouldn't notice a difference.

This was recently covered by Alan in his "Audiolofft":
http://www.axiomaudio.com/boards/ubbthreads.php?ubb=showflat&Number=261042

Even if you do end up with something with only balanced outputs, it is possible to turn a balanced out into a single-ended in with a simple cable. But the other way around is much more difficult.

Pioneer PDP-5020FD, Marantz SR6011
Axiom M5HP, VP160HP, QS8
Sony PS4, surround backs
-Chris