If your application is mostly movies, I would go with the 22s and use the extra $$$ to upgrade the sub. You will end up with a better system for movies thanks to the deeper bass and still have an amazing system for music since many have mentioned that M22s + sub sounds very close to M80s. Axiom subs are "musical" subs, accurate like the rest of their speakers. For movies I would be looking at other manufacturers like SVS, HSU, Elemental designs, etc... For the same price range, you could find a sub maybe not as good as Axiom for music but that would shake your whole house for movies a lot more than the EP350 or EP500.
