I think you might be able to get some M22's(on stands or beside the TV if the stand is large enough) and a Vp100/150 under/over the TV and the sub could go between the fireplace and sectional, kind of like an end table or under an endtable.

I had my old system corner loaded like that and the aforementioned set up worked great.

Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70