I haven't done a direct comparison between the M22's and M80's but a few members here say that M22 + sub is very similar sonically to M80's(+ sub?). Having said that, you are comparing M22's V1s to M80 V3s as well as a V1 EP150 to an EP180 V3, so there'll be an improvement there which will be more pronounced as the volume increases(you said same volume...I believe the differences will be more noticeable at higher listening levels due to cabinet volume, more drivers ect).

Half of communication is listening. You can't listen with your mouth.