Oh heck yes.

M22's and VP180 would be a great setup, especially with the Epik sub.

I want to very strongly encourage you to get the QS8's. They are really wonderful speakers. I think 5.1 with them would be much better than 7.1 with some kind of ceiling speaker compromise on the rears.

I think the alleged problems with the VP150 are overblown. I also think the VP180 is a killer, no compromise center channel.

M22's and a good sub will be great in that room.

bibere usque ad hilaritatem