If you can swing it, 3 M22's across the front for that size of room would be my recommendation, with the added benefit of the LCR being exactly the same, pans across the front are perfect.

Either of the subs you are looking at should work very well, I have heard both and each are very good, the EP350 is smoother while the PB12-nsd has a bit more upper bass punch, IMO.

Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70