Yes, the sub will be a must if your going with the M22's, however, for a better experience in the bass regions, M60's or M80's would be a better choice with a sub.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85