It will probably sound better than anything you heard before. I personally don't much believe in receiver/speaker matching.
That said, you have a large room, and larger mains, center and sub would be more ideal. M60s don't take much more floor space than M22s on stands. Of course M60s can't be bookshelf mounted like M22s. A VP150 center would be better for such a large room. Likewise a larger sub.
If you can't change anything else, maybe a larger sub such as the EP350 or Hsu STF-3 or VTF-3 Mk2 would be possible.
Some of this depends on how much home theater listening you do vs music. Conventional wisdom is for HT prioritize the sub, and for music prioritize the main speakers. But this varies. If your music has significant low freq. content such as organ music or hip-hop, a bigger sub is important. If your HT movies are mostly older classics with bandwidth limited stereo soundtracks, a bigger sub probably won't help.
But don't worry and get stuck over analyzing it. The system you listed will sound very good.
