I have the EP350 upstairs in our living room. The room is probably 15 x 20ish with a vaulted ceiling that goes from 8ft on one side upto about 12ft on the other. It also has a large opening that leads into the kitchen, and another opening on the other wall that leads to the front entryway and bedroom hallway.
The 350 does a wonderful job matched up with my M22's and VP100. I have the Denon receiver on 0dB, and the volume gain on the back of the sub at about 1/2 way and it produces very nice powerful bass when called upon.