My own experience with v2 Axioms took me to M80s + sub superior to M22 + sub, the M80/sub has a slightly warmer/fuller sound yet maintaining that great midrange the M22s have. If you want to 'upgrade' go for the M80s. I found the M60+sub and M22 + sub to be some what equal in appeal with the M60 still having that warmer/fuller sound but less midrange than the M80/sub or the M22/sub as the others have mentioned. Most of this is really only noticeable with A/B testing and your own preferences may differ from mine.
