Jon,
No, the ceiling height is normal or a bit less. I always ask because often there will be a cathedral ceiling, which makes the room much bigger.
If you were content with music playback peaking in the 90-dB range (that's almost "very loud"), the M22ti's would do nicely (assuming you are using a good, powerful subwoofer).
My concern is with movie soundtrack playback. With well-mixed Dolby Digital soundtracks and adventure-type movies, there's a tendency to "crank it up" (I do this with movies like "The Bourne Identity" and similar fare) because we're used to maximum involvement in large cinemas equipped with huge horn-loaded sound systems.
Cranking it up in a room as large as yours with M22ti's would be a mistake. If you could be happy with 90-dB peaks at your listening area with movie soundtracks, then the M22ti's will do a good job. The VP150 plays much cleaner at loud levels than the VP100, so using a 150 would also help.
Regards,
