With a perforated screen, you definetly want 3 identical mains. I'd opt for 3 M80's, then 3 M60's. 3 M22's with sub would work ok if you're restricted financially, or spacewise.

I would not assume any particular placement for the sub. It might not work as well in front as off to the side or even a rear room position. Only experience with moving the sub and/or using the sub crawl technic will determine the best location.